CEMO is delighted to announce the seminar of the department that will be given by PhD students and PostDocs.

The seminar will be followed by a lunch (kindly provided by the department) in order to allow everybody to interact and promote collaborations between labs.

Agenda:

12h00 - “Golgi structural proteins as novel effectors in the Reelin-regulated Functions during the Development of the Mammalian Cerebral Cortex” - Elisa Calvo Jiménez (MACE lab)

Abstract:

The cerebral cortex is composed of different types of neurons that accumulate into 6 layers according to their birth date. Excitatory neurons, the major type in the cortex, are born in a region of the cerebral wall called the ventricular zone and migrate radially (as described in the figure) to reach their final destination in the cortical plate and complete their maturation. Fully differentiated neurons carry an axon and multiple dendrites, and present both morphological and functional polarization. During radial migration, these neurons switch between multipolar and bipolar migrations accompanied by changes in polarity. In most cells, the Golgi apparatus is crucially involved in polarity establishment. In neurons, its location is key in migration, axon specification and dendrite development.

The Reelin signaling, one of the major pathways regulating brain development, has been described to regulate the orientation of the Golgi during multipolar migration and to induce the translocation of the Golgi into the main apical dendrite after completion of migration.

The laboratory has demonstrated the implication of Rap1, NCad and FGFRs downstream of Reelin to orient neurons towards the cortical plate. We are now investigating whether they are also involved in the dendrite development and in the regulation of the Golgi apparatus.

12h45 - Q&A session

13h00 - Lunch